e-NIOS, is an SME (5 employees as of 5/2/2014) working in the analysis of high throughput molecular data. It was founded in July 2013 (Athens, Greece) by a multi-disciplinary research team with expertise in Molecular/Systems Biology, Engineering and Information Technology, namely Research Associate Professor Aristotle Chatziioannou, Dr. Elefterios Pilais and Dr. Ioannis Valavanis.
e-NIOS is a spin-off company, which emerged from the research activities of the Group of Bioinformatics and Metabolic Engineering of the National Hellenic Research Foundation (NHRF) in the areas of Bioinformatics and In Silico Systems Biology. The company holds an active collaboration with the Institute of Biology, Medicinal Chemistry & Biotechnology at NHRF, where e-NIOS founding members have conducted research in the fields of Bioinformatics, Metabolomics and Data-Mining. e-NIOS received substantial support by initiatives promoting innovation and entrepreneurship in Greece and lately was granted 100K seed funding for its early development. The company is currently based at Al. Pantou 25 (Kallithea) in Athens and is a Private Company (I.K.E.) legal entity.
e-NIOS’ mission is to accelerate cutting edge research and innovative health services in the field of personalized (precision) medicine, through the development of software solutions. e-NIOS solutions target the whole analysis of genomic data, encompassing the experimental design, whereas numerous protocols (i.e. Next Generation Sequencing, Microarrays, Proteomics, Metabolomics), yielding different types of genomic information are supported. The data process incorporates all stages starting from the digitized -omic data as generated from the sequencer or the microarray chip, to the final biological interpretation, tackling effectively the observed complexity and ranking critical molecular actors. Identification of key events regarding the structure and/ or function of molecular players (genes, proteins, mutations etc.), as well as examination of their effect in the tangible, broader molecular networks that dynamically participate in the manifestation of the cell’s response, represent rational targets for diagnostic purposes, targeted therapeutic approaches (theranostics) and systemic interpretation of the molecular etiology of diseases. e-NIOS software solutions perform systemic interpretation of the analyzed data integrating rationally the individual players and their interactions, into the engaged cellular pathways, and molecular networks. Two related Software as a Service (SaaS) products are currently developed, expected to become available since October 2015. Apart from providing fine-tuned, generic computational workflows for efficient integrative -omic data analysis, e-NIOS may support research teams, industry partners, or individual scientists with tailor-made solutions to meet their particular analytical needs.
Target Partners & Collaborations
e-NIOS seeks collaborations at a national and international level in order to jointly promote knowledge discovery in Biology and develop innovative applications in Biotechnology, Drug Discovery and Personalized Medicine. Our target partners include molecular diagnostics centers, biotechnology research groups, pharmaceutical companies and medical departments with a personalised medicine orientation.
Technologies / Services offered or sought
e-NIOS conducts research in the fields of high-throughput molecular data analysis, biological data interpretation (biological pathways, molecular mechanisms, biomarkers discovery), data analytics/ mining, and computational workflows in cloud environment. e-NIOS R&D department works closely with the Group of Bioinformatics and Metabolic Engineering at the Institute of Biology, Medicinal Chemistry & Biotechnology at NHRF.
e-NIOS founders have been involved in several EU and nationally funded R&D projects, from their positions they hold at NHRF (Prinicipal Investigator, Post-Docs). Some examples follow:
HotZyme: Microbial diversity and metagenomic mining for biotechnological innovation, entitled « Systematic screening for novel hydrolases from hot environments)» (FP7- Call: KBBE-2010.3.5-04,2011-2015).
Envirogenomarkers: Genomics biomarkers of environmental health (Medium-scale focused research project, EU FP7, 2009-2013).
e-LICO: e-Laboratory for Interdisciplinary Collaborative Research in Data Mining and Data-Intensive Sciences (FP7- ICT-2007.4.4 Intelligent Content and Semantics, 2009-2012).
PROMISE: Personalization of melanoma therapeutic management through the fusion of systems biology and intelligent data mining methodologies ( Bilateral Research and Technology Cooperation between Greece and China, 2013-2015)
Clients & Collaborations (NATIONAL)
e-NIOS has built collaborations with Universities, Research Centers or Private Organizations in Greece or abroad. Some of the collaborator / partners in Greece are the Laboratory of Biotechnology (School of Chemical Engineering at the National Technical University of Athens), ProATonce, HISTBIO Diagnosis, Genekor and Lab Supplies companies. e-NIOS founding members also hold strong relationships with various research laboratories at the Institute of Biology, Medicinal Chemistry & Biotechnology at NHRF.
Clients & Collaborations (INTERNATIONAL)
Collaborations abroad include the Deutches Krebsforsung Zentrum (Heidelberg, Germany) and the Neuroinflammation, Imaging and Therapy of Multiple Sclerosis Lab (INSERM- University of Bordeaux, France).